قسم الكيمياء الطبية والصيدلية

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حول قسم الكيمياء الطبية والصيدلية

يعتبر قسم الكيمياء الطبية والصيدلية أحد فروع علم الكيمياء المُتقاطعة مع الكيمياء العضوية الصناعية، علم الصيدلة وعلم الأدوية وغيره من التخصصات البيولوجية حيث تُعنى بتركيبة المواد الصيدلانية أو الجزيئات النشطة بيولوجياً (الأدوية) وتصنيعها الكيميائي وتطوّر تسويقها ويشمل علم الكيمياء الصيدلية في مظهره الاهتمام بدراسة الأدوية من حيث الانحلال والارتباط  بالبروتينات والامتصاص والاطراح، وبعضها يذهب إلى الاهتمام بدراسة الطرق التحليلية لهذه الادوية. كما تشمل الكيمياء الطبية في مظهرها العام على الكيمياء العضوية الصناعية، جوانب المنتجات الطبيعية والكيمياء الحسابية واقترانهم بالبيولوجيا الكيميائية، علم الأنزيمات، البيولوجيا البنائية، كما يشكل القسم مجموعة من العلوم مُتعددة التخصصات كما تضبط ركائزها العضوية، الفيزيائية والحسابية بجانب الحقول البيولوجية كالكيمياء الحيوية، البيولوجيا الجزيئية، علم الصيدلة، علم العقاقير الصيدلانية، علم السموم، الطب البيطري والطب البشري.  كما يشمل القسم علوم ذات تخصصات متعددة، ويتميّز ممارسوه بخلفية قويّة في الكيمياء العامة والعضوية والتحليلية إلى جانب فهم المبادئ البيولوجية المتعلقة باستهداف العقاقير الدوائية، ويتميّز أساتذة وبحاث القسم بعملهم ضمن فريق مُتعدد التخصصات الذين يستخدمون قدراتهم الكيميائية لاستخدام المباديء الكيميائية لتصميم عقارات علاجية فاعلة وتحليلها ومراقبة جودتها.

منشورات مختارة

بعض المنشورات التي تم نشرها في قسم الكيمياء الطبية والصيدلية

Separation of complexed semi-synthetic flavonoids by using fused core column in short time

Hydroxyethylrutosides (Troxerutin) is a standardized mixture of semi-synthetic flavonoids obtained by substituting hydroxyethyl groups in the naturally occurring flavonol rutin. Because there are four dissociation hydroxyls in rutin, some fifteen kinds of hydroxyethylrutins can be theoretically synthesized. The good quality of the raw material of a drug and the finished product must include the related impurities in an analytical investigation, and this seemed particularly important to the quality control of Troxerutin. According to the literature, it is clear that, the chromatographic analysis of Troxerutin still problematic as its sample can be considered as a complex sample as it contains plenty of different components. In this study, new HPLC technology named fused- core column was used to separate the major components of Troxerutin bulk powder. Fused – Core silica stationary phases represent key technological advancement in the area of fast HPLC separations. These phases are made by fusing 0.5 μm porous silica. The reduced intra – particle flow path of the fused particles provides superior mass transfer kinetics and better performance at high mobile phase velocities, while the fused – core particles provide lower pressure than sub – 2 μm particles. arabic 13 English 77
Sakina Salem Mohammed Saadawi, AMAL .A ABOALLA AMMAR, Mohamed Nouri Mansour El Attug, Amal Khalifa Ali Belaid, ٌRuwida Mohamed Ali Kamour, Tariq Khalifa Masoud Almog(1-2016)
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Study of Caffeine Consumption Rate and Concentration in Different Food and Beverages Consumed by Libyan Children

Caffeine is the most commonly used psychoactive substance throughout the world. It is found in coffee, black tea, and chocolate, as it is produced naturally in the beans and leaves of the plants used to manufacture these products. This study aimed to make a survey study among children 2-11 years in some Tripoli, Libya schools to determine caffeine concentration in number of beverages and foods consumed by studied children. About 313 copies of the questionnaire were distributed to students to be filled by their parents. Caffeine was extracted from samples using dichloromethane. Purity of isolated caffeine was estimated by using TLC method.Quantitative analysis of caffeine was performed by using a UV-Visible spectrophotometer. Chocolate biscuits, chocolate cake, cocoa milk and chocolate ice cream were the highest consumed products among the studied children (81%, 79%, 67% and 63% respectively). The highest side effects of caffeine consumption was hyperactivity was the highest side effect in children (76%). Some children also suffered from severe side effects such as panic attack (14%). Naseem ice cream sample showed the highest caffeine content (28 mg/serving) among solid samples.Whereas in the beverages, energy drink samples Red pull, XIR and Shark were 268, 262 and 250 mg/serving respectively. In conclusion, there was excessive consumption of caffeine among the studied group of children and some of them showed side effects and even severe side effects. Variety of tested foods and beverages under the study contained uncontrolled concentrations of caffeine. In addition, chocolate milk (Al Rayhan), contained no caffeine. arabic 15 English 97
Sakina S. Saadawi, Khairi A. Alennabi, AMAL .A ABOALLA AMMAR, , , ٍSuhera Mehemed Abdulsalam Aburawi(9-2019)
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Quality control of home grinded against ready prepared chosen spices from Libyan market

Spices are any pungent, aromatic plant substances used to flavor food or beverages. Plant foods and agricultural commodities including spices are increasingly subjected to adulteration by design or default. This study aimed to compare home grinded spices against ready locally prepared ones in Libyan market. Chosen spices were compared according to their percentage of yield, organoleptic features, and pharmacognostic parameters as macroscopic and microscopic characteristics, pH measurement, microbial contamination (total viable count and microbial identification), and thin layer chromatography (TLC) chromatogram and diphenyl picryl hydrazyl (DPPH) scavenging activity. From the results, the ready prepared samples showed to have higher percentage of yield compared to home prepared ones. There were no difference in organoleptic test results, macroscopic and microscopic characteristics and pH test results. Bacteria in spices samples were too many to count (TMTC) in most samples, however thyme, rosemary and cinnamon showed better results. The isolated bacteria were identified as Salmonella, Shigella and E. coli species. TLC chromatogram and DPPH scavenging activity test also showed no difference in both sample groups. All these tests indicates that the samples obtained from market as grinded powder and the same samples of spices that was brought as a raw materials and grinded at home had the same characteristics, which indicated that they are of the same quality which not necessary to be a good one. arabic 12 English 75
Sakina Salem Mohammed Saadawi, , , AMAL .A ABOALLA AMMAR, (1-2015)
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