Department of Medical chemistry

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About Department of Medical chemistry

Who works at the Department of Medical chemistry

Department of Medical chemistry has more than 19 academic staff members

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Dr. Mohamed Nouri Mansour El Attug

د.العتوق هو احد اعضاء هيئة التدريس بقسم الكيمياء الطبية والصيدلية بكلية الصيدلة. يعمل السيد العتوق بجامعة طرابلس كـاستاذ مساعد منذ 2015-08-24 وله العديد من المنشورات العلمية في مجال تخصصه


Some of publications in Department of Medical chemistry

Separation of complexed semi-synthetic flavonoids by using fused core column in short time

Hydroxyethylrutosides (Troxerutin) is a standardized mixture of semi-synthetic flavonoids obtained by substituting hydroxyethyl groups in the naturally occurring flavonol rutin. Because there are four dissociation hydroxyls in rutin, some fifteen kinds of hydroxyethylrutins can be theoretically synthesized. The good quality of the raw material of a drug and the finished product must include the related impurities in an analytical investigation, and this seemed particularly important to the quality control of Troxerutin. According to the literature, it is clear that, the chromatographic analysis of Troxerutin still problematic as its sample can be considered as a complex sample as it contains plenty of different components. In this study, new HPLC technology named fused- core column was used to separate the major components of Troxerutin bulk powder. Fused – Core silica stationary phases represent key technological advancement in the area of fast HPLC separations. These phases are made by fusing 0.5 μm porous silica. The reduced intra – particle flow path of the fused particles provides superior mass transfer kinetics and better performance at high mobile phase velocities, while the fused – core particles provide lower pressure than sub – 2 μm particles. arabic 13 English 77
Sakina Salem Mohammed Saadawi, AMAL .A ABOALLA AMMAR, Mohamed Nouri Mansour El Attug, Amal Khalifa Ali Belaid, ٌRuwida Mohamed Ali Kamour, Tariq Khalifa Masoud Almog(1-2016)
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Study of Caffeine Consumption Rate and Concentration in Different Food and Beverages Consumed by Libyan Children

Caffeine is the most commonly used psychoactive substance throughout the world. It is found in coffee, black tea, and chocolate, as it is produced naturally in the beans and leaves of the plants used to manufacture these products. This study aimed to make a survey study among children 2-11 years in some Tripoli, Libya schools to determine caffeine concentration in number of beverages and foods consumed by studied children. About 313 copies of the questionnaire were distributed to students to be filled by their parents. Caffeine was extracted from samples using dichloromethane. Purity of isolated caffeine was estimated by using TLC method.Quantitative analysis of caffeine was performed by using a UV-Visible spectrophotometer. Chocolate biscuits, chocolate cake, cocoa milk and chocolate ice cream were the highest consumed products among the studied children (81%, 79%, 67% and 63% respectively). The highest side effects of caffeine consumption was hyperactivity was the highest side effect in children (76%). Some children also suffered from severe side effects such as panic attack (14%). Naseem ice cream sample showed the highest caffeine content (28 mg/serving) among solid samples.Whereas in the beverages, energy drink samples Red pull, XIR and Shark were 268, 262 and 250 mg/serving respectively. In conclusion, there was excessive consumption of caffeine among the studied group of children and some of them showed side effects and even severe side effects. Variety of tested foods and beverages under the study contained uncontrolled concentrations of caffeine. In addition, chocolate milk (Al Rayhan), contained no caffeine. arabic 15 English 97
Sakina S. Saadawi, Khairi A. Alennabi, AMAL .A ABOALLA AMMAR, , , ٍSuhera Mehemed Abdulsalam Aburawi(9-2019)
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Phytoremediation effect of Ricinus communis, Malva parviflora and Triticum repens on crude oil contaminated soil

Oil and its derivatives spills have been a major issue across decades and it is hard to biodegrade even though there are many techniques are being developed to clean up petroleum contaminated soil. Phytoremediation has long been applied as a treatment technology that is cost-effective, ecologically friendly and efficient for the decontamination of hydrocarbon pollution. In this study, four crude oil contaminated soil samples were collected from oil extraction fields in Libya. Three plants were chosen (Malva punilora, Ricinus communis and Triticum repens) on 0.5% and 1% crude oil contaminated soil .The chosen plant species were implanted individually in the contaminated soil pots. Soil sample (triplicate) was taken from each pot at zero time, after 15 days. After 30 days and after 45 days of experiment. Hexane was added to the soil samples, mixed, filtered and the absorbance was measured using spectrophotometer at 360 nm. The results were compared to the standard curve to calculate the crude oil concentration and percentage of removal. As a result the highest percentage of removal of 0.5 % crude oil contaminated soil was by Triticum repens (94%) after 30 days of experiment followed by Malva parviflora(88.5) and Ricinus communis(77 %). While in 1% crude oil contaminated soil pots experiment, the highest percentage of removal was by Malva parviflora (89%) after 30 days of experiment followed by Triticum repens (80%) and Ricinus communis (76 %). Triticum repens showed good results suggesting more field application. arabic 15 English 97
Sakina Salem Mohammed Saadawi, , AMAL .A ABOALLA AMMAR, , (1-2015)
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